ERα-NOS/NO/cGMP/PKG-mTOR/KITL/FOXO3a signaling cascade mediates estrogen-induced primordial follicle activation in goats.
ERα-NOS/NO/cGMP/PKG-mTOR/KITL/FOXO3a signalizační kaskáda zprostředkovává aktivaci prvosmyslového folikulu indukovanou estrogenem u koz
J Dairy Sci. 2026 Apr;109(4):4496-4515. doi: 10.3168/jds.2025-27037. Epub 2026 Jan 20.
PMID: 41570914  
Multi-omics integration and machine learning unveil FOXO3/SIRT1 axis as oxidative stress biomarkers and therapeutic targets in osteoporosis.
Zheng S, Luo X, Chen G, Wang P.
Medicine (Baltimore). 2026 Jan 30

LncRNA FTX/OCT4/miR-122-5p orchestrates self-renewal and lineage commitment of human dental pulp stem cells by directly targeting FOXO3. Zeng K, Wu L, Xin W, Cui C, Mai S, Hong H, Wei X.
Stem Cell Res Ther. 2025 Oct 15

FGF/FGFR axis
Targeting the FGF/FGFR axis and its co-alteration allies. Uehara Y, Ikeda S, Kim KH, Lim HJ, Adashek JJ, Persha HE, Okamura R, Lee S, Sicklick JK, Kato S, Kurzrock R.
ESMO Open. 2022 Dec;7(6):100647. doi: 10.1016/j.esmoop.2022.100647. Epub 2022 Nov 29.
PMID: 36455506

JAK/STAT and IRS/PI3K signaling
The pivotal role of JAK/STAT and IRS/PI3K signaling pathways in neurodegenerative diseases: Mechanistic approaches to polyphenols and alkaloids. Kooshki L, Zarneshan SN, Fakhri S, Moradi SZ, Echeverria J.
Phytomedicine. 2023 Jan 31;112:154686. doi: 10.1016/j.phymed.2023.154686. Online ahead of print.
PMID: 36804755

JAKinhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes. Shao S, Chen C, Shi G, Zhou Y, Wei Y, Wu L, Sun L, Zhang T.
Acta Pharm Sin B. 2023 Oct;13(10):4185-4201. doi: 10.1016/j.apsb.2023.07.026. Epub 2023 Jul 31.
PMID: 37799385 Free PMC article.

The JAK-STAT signaling pathway in inflammatory and autoimmune diseases: Its potential role as a therapeutic target.
Signální dráha JAK-STAT u zánětlivých a autoimunitních onemocnění

JAK2/STAT3 pathway inhibition by AG490 ameliorates experimental autoimmune encephalomyelitis via regulation of Th17 cells and autophagy. Xue Y, Zhang L, Chu L, Song Z, Zhang B, Su X, Liu W, Li X.
Neuroscience. 2024 Jun 15:S0306-4522(24)00266-5. doi: 10.1016/j.neuroscience.2024.06.009. Online ahead of print.
PMID: 38885894

Klotho inhibits IGF1R/PI3K/AKTsignalling pathway and protects the heart from oxidative stress during ischemia/reperfusion injury. Olejnik A, Radajewska A, Krzywonos-Zawadzka A, Bil-Lula I.
Sci Rep. 2023 Nov 20;13(1):20312. doi: 10.1038/s41598-023-47686-5.
PMID: 37985893